Test Catalog

Test Id : FBAC

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Bile Acids, Urine

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Overview

Test Catalog

Method Name
A short description of the method used to perform the test

Fast Atom Bombardment-Mass Spectrometry (FAB-MS)

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Bile Acids, Urine

Aliases
Lists additional common names for a test, as an aid in searching

FAB Testing

Bile Acids Urine

FBAC

.

Specimen Type
Describes the specimen type validated for testing

Urine

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Collection Container: Plastic urine container

Specimen Volume: 5-25 mL

Collection Instructions:

  1. Collect 5-25 mL random urine without preservative.
  2. Ship frozen in a plastic container.

 

NOTE: Submit with specimen:

1. Clinical history/Preliminary diagnosis

 

-Because URSO can mask detection of bile acid synthetic defects it is preferable for patients to be off Urso or Actigall for 5 days before sample collection.

 

-If possible, send Urine & Serum (ZW166 - Bile Acids Serum, referral lab code 9001004). Urine is analyzed for all patients - if Urine shows evidence of a metabolic abnormality, Serum will be tested. Urine and serum must be ordered separately as they are 2 separate tests with separate charges.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

1 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis NA
Lipemia NA
Icterus NA
Other Collection in or on diaper or cotton balls

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Urine Frozen (preferred)
Ambient 48 hours
Refrigerated 48 hours

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Diagnostic testing in pediatric and adult patients presenting with conditions of cholestatic liver disease, neurological disease, or fat-soluble vitamin malabsorption of unknown etiology. Urine FAB-MS analysis provides a rapid and cost-effective means of diagnosing the most common of the genetic defects in the metabolism of cholesterol to the primary bile acids. Mass spectrometry testing may be used to monitor the biochemical response to primary bile acid therapy and to help in decisions on dose adjustments, where compliance should lead to a reduction in levels of atypical bile acids.

Method Description
Describes how the test is performed and provides a method-specific reference

Application of liquid secondary ionization mass spectrometry using fast atom bombardment (FAB-MS) ionization to detect the negative ions associated with the presence of increased concentrations of atypical bile acids in urine resulting from the loss of activity of one of the key enzymes that catalyze the production of normal primary bile acids by the liver. Each enzyme defect yields a distinct and specific mass spectrum that permits the diagnosis of the genetic defect.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

Referral

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

7 to 30 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Cincinnati Childrens Hosp Med CTR Core Laboratories

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its performance characteristics were determined and validated by the Clinical Mass Spectrometry Laboratory at Cincinnati Childrens Hospital Medical Center. It has not been cleared or approved by the U. S. Food and Drug Administration. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA 88) as qualified to perform high-complexity laboratory testing.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

83789

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FBAC Bile Acids, Urine 49254-6
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
FBAC Bile Acids, Urine 49254-6

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports