Test Catalog

Test Id : FGAGM

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Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies

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Overview

Test Catalog

Method Name
A short description of the method used to perform the test

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Ganglioside Antibodies, IgG-IgM

Aliases
Lists additional common names for a test, as an aid in searching

GM1 COMBI FORWARD

Anti-GM Antibodies FORWARD

Asialo-GM1 Antibodies, IgG and IgM FORWARD

Asialo-GM1, GM1, GD1b, GQ1b IgG and IgM FORWARD

Ganglioside Antibodies FORWARD

Ganglioside Abs IgG and IgM FORWARD

GM1, GM2, GD1a, GD1b, GQ1b IgG/IgM FORWARD

Specimen Type
Describes the specimen type validated for testing

Serum SST

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Draw blood in a serum gel tube(s). Spin down and send 1 mL of serum refrigerated in a plastic vial.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the testing laboratory. The minimum volume is sufficient for one attempt at testing.

0.3 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Hemolysis Mild OK; Grossly Reject
Lipemia Mild OK; Grossly Reject
Icterus Mild OK; Grossly Reject
Other Plasma, CSF, or other body fluids. Contaminated, heat-inactivated specimens

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum SST Refrigerated (preferred) 14 days
Frozen 365 days

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

29 IV or less

Negative

30-50 IV

Equivocal

51-100 IV

Positive

101 IV or greater

Strong Positive

Interpretation
Provides information to assist in interpretation of the test results

Ganglioside antibodies are associated with diverse peripheral neuropathies.  Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy.  Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies.  These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80 percent of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday, Wednesday, Friday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

1 to 8 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

ARUP Laboratories

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

83516 x 6

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
FGAGM Ganglioside Antibodies, IgG-IgM 82455-7
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Z4245 Asialo-GM1 Antibodies, IgG-IgM 88723-2
Z4246 GM1 Antibodies, IgG-IgM 31500-2
Z4247 GM2 Antibodies, IgG-IgM 88731-5
Z4248 GD1a Antibodies, IgG-IgM 88724-0
Z4249 GD1b Antibodies, IgG-IgM 88730-7
Z4250 GQ1b Antibodies, IgG-IgM 88729-9

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports

Test Update Resources

Change Type Effective Date
Test Changes - Referral Fee 2024-01-05
Test Status - Test Resumed 2023-07-14
Test Status - Test Down 2023-06-22
Test Changes - Referral Fee 2023-02-02